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[5] While copper can potentially cause skin irritation or toxicity, in vitro studies suggest that GHK-Cu complexes may have a lower likelihood of inducing these effects

As a direct measurement of unbound concentrations of drugs (C u,cell ) inside the brain parenchymal cells cannot be achieved in practice, indirect methods combining the brain slice assay and brain homogenate method have been established to estimate C u,cell (97, 104)